EDT (1149 GMT). Thus, it is not clear whether observer buy runescape 3 gold bias in clinical trials, on average, is negligible or large or how variable the size and direction of any observer bias is or which factors in a trial are associated with a more pronounced degree of bias.A reliable evaluation of the impact of non blinded outcome assessors in randomised clinical trials is important, both to guide the design of future trials and to assist the balanced interpretation of trial results for example, in the assessment of the risk of bias in trials for meta analysis.1 It also seems important for evidence based medicine to strengthen its own evidence base.We systematically reviewed randomised trials with blinded and non blinded assessors of binary outcomes to evaluate the impact of non blinded outcome assessment on estimated treatment effects in randomised clinical trials and to examine reasons for its variation.MethodsWe included randomised clinical trials with blinded and non blinded assessment of the same binary outcome.
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